HCID 87950499, 화합물 → HCID 18469986, 화합물

HRID 2228448노트

반응식

HRID 2228448 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:36])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])=[CH:25][CH:24]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:33][C:31]([F:32])([F:34])[C:30]([NH:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][C:20](=[O:36])[C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:15][CH:16]=2)=[CH:28][CH:27]=1)=[O:35]

참가 물질

4

반응물 1

HCID 87950499HCID 87950499, 화합물

생성물 1

HCID 18469986HCID 18469986, 화합물수율 96.2%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A suspension of 4-(4-{3-[4-(2,2,2-trifluoroacetylamino)phenyl]propionyl}-phenyl)piperazine-1-carboxylic acid tert-butyl ester (2.5 g, 4.95 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (10 mL) was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and diluted with water. The resultant white solid was collected, washed with water, dried in vacuo to give the title compound (1.93 g, 96%). The product was used in the next step without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water
  3. customThe resultant white solid was collected
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-9c4ad7f779a94c68a26c37476c9eec9a
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06417186B1

반응 노트

불러오는 중…