3,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione → 3,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

HRID 2228456노트

반응식

HRID 2228456 반응식
[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][N:7]1CC1C=CC=CC=1)=[O:5]>CCO.[Pd]>[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][NH:7]1)=[O:5]

참가 물질

4

반응물 1

HCID 184700773,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione

생성물 1

HCID 694178043,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

1 g 10% Pd/C was added to a solution of 3,3-dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione (7.0 g, 20.2 mmol) in 70 ml EtOH. The mixture was under hydrogenation at room pressure (1 atm) overnight. The product was obtained as white solid after filtering Pd catalyst and concentration (3.8 g, 89%). 1H NMR (CDCl3, 400 MHz) δ 0.88 (t, 3H, J=7.0); 1.19 (s, 6H); 1.65 (m, 4H); 1.79 (m, 2H); 2.85 (m, 2H); 3.42 (m, 1H); 3.56 (m, 1H).

후처리

  1. customwas under hydrogenation at room pressure (1 atm) overnight
  2. customThe product was obtained as white solid
  3. filtrationafter filtering
  4. concentrationPd catalyst and concentration (3.8 g, 89%)

출처 및 근거

ORD 기록
ord-d65e097f93674abca697f319e99165bb
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06417189B1

반응 노트

불러오는 중…