2-Benzyloxy-3,4-dimethoxybenzonitrile → 2-Hydroxy-3,4-dimethoxybenzonitrile
반응식
C([O:8][C:9]1[C:16]([O:17][CH3:18])=[C:15]([O:19][CH3:20])[CH:14]=[CH:13][C:10]=1[C:11]#[N:12])C1C=CC=CC=1>[Pd].C(O)C>[OH:8][C:9]1[C:16]([O:17][CH3:18])=[C:15]([O:19][CH3:20])[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]참가 물질
4
실험 절차
10% palladium on charcoal (2.0 g) was added to a solution of 2-benzyloxy-3,4-dimethoxybenzonitrile (20.8 g, 0.077 mol) in ethanol (250 ml) and the reaction stirred under a hydrogen atmosphere of 414 kPa (60 p.s.i.) for 4 hours. On cooling, the mixture was filtered through Arbocel™, washing with further ethanol. The filtrate was evaporated under reduced pressure to give the subtitle compound as a yellow solid (13.37 g, 97%). Rf 0.19 (dichloromethane). MS m/z 197 (MNH4)+.
후처리
- temperatureOn cooling
- filtrationthe mixture was filtered through Arbocel™
- washwashing with further ethanol
- customThe filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-6cbe3970b6884e909c76703a8dd8bf4b
- 출처 데이터셋
- uspto-grants-2002_07
- 특허 번호
- US06417194B1
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