Bromocyclopentane → 2-Cyclopentyloxy-3,4-dimethoxybenzonitrile

반응식

[OH:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH:14]1(Br)[CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH:14]1([O:1][C:2]2[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 8728Bromocyclopentane

HCID 119947582-Hydroxy-3,4-dimethoxybenzonitrile

생성물 1

HCID 184706462-Cyclopentyloxy-3,4-dimethoxybenzonitrile수율 95%

실험 절차

The subtitle compound was prepared from 2-hydroxy-3,4-dimethoxybenzonitrile and freshly distilled cyclopentyl bromide following the procedure described in Example 10(d). The crude product was purified on silica gel eluting with dichloromethane to give the subtitle compound as a colourless oil (95%). Rf 0.50 (dichloromethane). MS m/z 265 (MNH4)+.

후처리

customThe crude product was purified on silica gel eluting with dichloromethane

출처 및 근거

ORD 기록: ord-80b43739db624a9f8b64d556ab864f59
출처 데이터셋: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06417194B1

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