Ethyl 3-(pyrimidin-5-yl)prop-2-enoate → Ethyl 3-(5-pyrimidyl)propionate

HRID 2228908노트

반응식

HRID 2228908 반응식
[N:1]1[CH:6]=[C:5]([CH:7]=[CH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3][CH:2]=1

참가 물질

4

반응물 1

HCID 53438539Ethyl 3-(pyrimidin-5-yl)prop-2-enoate

생성물 1

HCID 21936199Ethyl 3-(5-pyrimidyl)propionate수율 47.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of ethyl 3-(5-pyrimidyl)acrylate (4.75 g) in ethanol (90 ml) was added 5% palladium on charcoal (0.2 g). The mixture was hydrogenated at an initial pressure of 50 psi, then filtered to remove catalyst and the solvent evaporated. Water was added, and the product extracted into ether. Drying, charcoaling and evaporation gave ethyl 3-(5-pyrimidyl)propionate (2.3 g) as a yellow oil. 1H-NMR (CDCl3) δ 1.23 (3H, t), 2.69 (2H, t), 2.96 (2H, t), 4.14 (2H, q), 8.635 (2H, s) and 9.09 (1H, s).

후처리

  1. filtrationfiltered
  2. customto remove catalyst
  3. customthe solvent evaporated
  4. additionWater was added
  5. extractionthe product extracted into ether
  6. customDrying
  7. customcharcoaling and evaporation

출처 및 근거

ORD 기록
ord-5845df4c4a6b4e97b04c1c946e30da3a
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06417192B1

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