2,3-Dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-1-ol → 2,3-Dihydropyrrolo[1,2-a]benzimidazol-1-one
반응식
[OH:1][CH:2]1[N:9]2[C:5](=[N:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)[CH2:4][CH2:3]1>C(Cl)Cl.C(OCC)(=O)C>[O:1]=[C:2]1[N:9]2[C:5](=[N:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)[CH2:4][CH2:3]1참가 물질
4
실험 절차
A solution of 2,3-dihydro-1-hydroxy-1H-pyrrolo-[1,2-a]benzimidazole (1.0 g, 5.75 mmol)) in methylene chloride was treated with mangenese dioxide (5 g, 58 mmol) at r.t. and stirred for 10 hour. The mixture was diluted with ethyl acetate and filtered through diatomaceous earth (Celite (trademark)). The filtrate was concentrated and purified to give the title compound. 1HNMR (CDCl3)δ 3.28 (t, 2H), 4.48 (t, 2H), 7.3-7.45 (m, 2H), 7.45-7.55 (m, 1H), 7.86-7.94 (m, 1H) ppm.
후처리
- filtrationfiltered through diatomaceous earth (Celite (trademark))
- concentrationThe filtrate was concentrated
- custompurified
출처 및 근거
- ORD 기록
- ord-82cb599521bc42b6af01acc980576057
- 출처 데이터셋
- uspto-grants-1995_06
- 특허 번호
- US05428043
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