Methanol → Methyl 3-chloro-4-isopropoxybenzoate

참여 물질

역할	이름	HCID	투입량
반응물	Methanol	HCID 887	—
반응물	Thionyl Chloride	HCID 24386	—
반응물	3-Chloro-4-(propan-2-yloxy)benzoic acid	HCID 22597728	—
생성물	Methyl 3-chloro-4-isopropoxybenzoate	HCID 22597811	—

반응 단계

A solution of 3-chloro-4-[(1-methylethyl)oxy]benzoic acid (1.00 g, 4.66 mmol) in methanol (10.0 mL) was treated with SOCl2 (0.68 mL, 9.32 mmol). After stirring overnight at ambient temperature, the solution was concentrated in vacuo and taken on without purification. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.04 (d, J=2.3 Hz, 1H) 7.89 (dd, J=8.7, 2.1 Hz, 1H) 6.93 (d, J=8.6 Hz, 1H) 4.66 (qq, J=6.1 Hz, 1H) 3.88 (s, 3H) 1.41 (d, J=6.1 Hz, 6H). MS (ES+) m/e 229 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08207340B2
출처 데이터셋	uspto-grants-2012_06
ORD ID	ord-d598efe57d44464c8ca78922e0459f1e
출처 메모	uspto-grants-2012_06