Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane ethylacetate → 3-phenyl-3-{[3'-(1,3-thiazol-2-ylamino)[1,1'-biphenyl]-3-yl]sulfonylamino}-propanoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 반응물 | Ethyl 3-phenyl-3-{[3'-(1,3-thiazol-2-ylamino)[1,1'-biphenyl]-3-yl]sulfonylamino}-propanoate | HCID 21982424 | — |
| 용매 | Lithium Hydroxide | HCID 3939 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 3-phenyl-3-{[3'-(1,3-thiazol-2-ylamino)[1,1'-biphenyl]-3-yl]sulfonylamino}-propanoic Acid | HCID 21982497 | — |
반응 단계
0.2 g of Ethyl 3-phenyl-3-{[3′-(1,3-thiazol-2-ylamino)[1,1′-biphenyl]-3-yl]sulfonylamino}-propanoate 15.1.1 were saponified in 15 ml dimethoxyethane 12 ml water and 0.2 g LiOH. After aqueous work-up and flash chromatography (dichloromethane/methanol 10+1) 65 mg were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06420396B1 |
| 출처 데이터셋 | uspto-grants-2002_07 |
| ORD ID | ord-18625ab8afed4ed383808e070d3fef45 |
| 출처 메모 | uspto-grants-2002_07 |