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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 222954생성일: 2026년 10월 26일

1H-imidazol-2-ylmethanamine dihydrochloride → 6-chloro-N-(3-{8-(2,6-difluorophenyl)-2-[(1H-imidazol-2-ylmethyl)amino]-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methylphenyl)-3-pyridinecarboxamide

https://huagongshe.com/reaction/222954

반응식

참여 물질

역할이름HCID투입량
반응물1H-imidazol-2-ylmethanamine dihydrochlorideHCID 12417863—
반응물6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamideHCID 59212686—
생성물6-chloro-N-(3-{8-(2,6-difluorophenyl)-2-[(1H-imidazol-2-ylmethyl)amino]-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methylphenyl)-3-pyridinecarboxamideHCID 11947854—

반응 단계

The title compound was prepared as described in Example 1d from 6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamide and (1H-imidazol-2-ylmethyl)amine dihydrochloride: LC-MS m/z 599 (M+H)+, 1.92 min (ret time).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08207176B2
출처 데이터셋uspto-grants-2012_06
ORD IDord-542ec45549854c1693567b3b54266024
출처 메모uspto-grants-2012_06