Piperazine → 1-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine

HRID 2230099

반응식

HRID 2230099 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[CH:12][N:11]=[C:10]2[N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:15]=[CH:16][C:9]=12>C(O)(C)C>[C:17]1([N:14]2[C:10]3=[N:11][CH:12]=[N:13][C:8]([N:1]4[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]4)=[C:9]3[CH:16]=[N:15]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 2197524-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

생성물 1

HCID 8556141-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine수율 88%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To an isopropanol solution (10 mL) of piperazine (3.74 g, 43.4 mmol), 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine (100 g, 4.34 mmol) described in J. Org. Chem., 21: 1240-1256 (1956) was added, followed by heating under reflux for 6 hours. The reaction solution was concentrated, saturated brine was added thereto, the mixture was extracted with chloroform, the extract was washed with saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated to give the target compound (1.07 g, 3.82 mmol).

후처리

  1. addition, 21: 1240-1256 (1956) was added
  2. temperatureby heating
  3. temperatureunder reflux for 6 hours
  4. concentrationThe reaction solution was concentrated
  5. additionsaturated brine was added
  6. extractionthe mixture was extracted with chloroform
  7. washthe extract was washed with saturated brine
  8. dry with materialdried over anhydrous sodium sulfate
  9. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-8a92fe3fcece4356bb472dc60d350135
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06423716B1

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