Ethyl acetamidate hydrochloride → HCID 131723418, 화합물

HRID 2230392

반응식

HRID 2230392 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[C:8]=2[C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)[CH2:3][CH2:2]1.CCO[C:28]([C:30]([NH2:32])=[O:31])=[O:29].Cl>CCO>[C:28]1(=[O:29])[N:32]([N:1]2[CH2:2][CH2:3][CH:4]([C:7]3[NH:11][N:10]=[C:9]([C:12]4[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=4)[C:8]=3[C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[CH2:5][CH2:6]2)[C:30]1=[O:31]

참가 물질

4

반응물 2

HCID 19983589Ethyl acetamidate hydrochlorideHCID 22037479HCID 22037479, 화합물

생성물 1

HCID 131723418HCID 131723418, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 5-(4-piperidyl)-4-(4-pyridyl)-3-(4-fluorophenyl)pyrazole (Example C-2) (0.11 g, 0.35 mmol) in 2 mL EtOH was added ethyl acetamidate hydrochloride (0.065 g, 0.53 mmol) and the mixture was refluxed for 30 minutes. The solution was left at 5-10° C. for 16 h and filtered to obtain the title compound as a white solid: MS (M+H): 364 (base peak).

후처리

  1. temperaturethe mixture was refluxed for 30 minutes
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-7221527b57da424dade102d6b22d56bf
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06423713B1

연결된 노트

불러오는 중…