2-Oxo-3-benzoylamino-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid → (3S)-2-Oxo-3-(3,5-dichloro4-hydroxybenzoyl)amino-5-hydroxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide
반응식
C(OC(=O)CN1C2C=CC=CC=2NC[C@H](NC(OC(C)(C)C)=O)C1=O)C1C=CC=CC=1.O=C1N(CC(O)=O)C2C=CC=CC=2N(C(=O)C)CC1NC(=O)C1C=CC=CC=1.[O:60]=[C:61]1[N:67]([CH2:68][C:69]([NH:71][C@H:72]2[CH2:76][C:75](=[O:77])[O:74][CH:73]2[O:78][CH2:79][C:80]2[CH:85]=[CH:84][CH:83]=[CH:82][CH:81]=2)=[O:70])[C:66]2[CH:86]=[CH:87][CH:88]=[CH:89][C:65]=2[N:64]([C:90](=[O:94])[CH2:91][O:92]C)[CH2:63][C@@H:62]1[NH:95][C:96](=[O:106])[C:97]1[CH:102]=[C:101]([Cl:103])[C:100]([OH:104])=[C:99]([Cl:105])[CH:98]=1>>[O:60]=[C:61]1[N:67]([CH2:68][C:69]([NH:71][C@H:72]2[CH2:76][C:75](=[O:77])[O:74][CH:73]2[O:78][CH2:79][C:80]2[CH:81]=[CH:82][CH:83]=[CH:84][CH:85]=2)=[O:70])[C:66]2[CH:86]=[CH:87][CH:88]=[CH:89][C:65]=2[N:64]([C:90](=[O:94])[CH2:91][OH:92])[CH2:63][C@@H:62]1[NH:95][C:96](=[O:106])[C:97]1[CH:98]=[C:99]([Cl:105])[C:100]([OH:104])=[C:101]([Cl:103])[CH:102]=1참가 물질
4
반응물 3
HCID 184657172-Oxo-3-benzoylamino-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid
HCID 22954562(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-methoxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide
HCID 57313411HCID 57313411, 화합물2회생성물 1
실험 절차
was synthesized from 600b via methods used to prepare 661 from 600b, excluding steps used to make 604d from 603d, using instead the method to prepare 688a from 678a to afford 854 mg of 692a, 1H NMR (CD3OD) δ2.45(d, 1H), 2.6(m, 1H), 2.7(m, 1H), 3.0(m, 1H), 3.5-3.7(m, 4H), 4.0(q, 2H), 4.45(m,3H), 4.55(m, 4H), 5.35(s, 1H), 5.6(d, 1H), 7.2-7.5(m, 9H), 7.85(s, 2H).
출처 및 근거
- ORD 기록
- ord-a9bcb6c6e03542a0b6f3147e64202e7b
- 출처 데이터셋
- uspto-grants-2002_07
- 특허 번호
- US06423840B1
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