(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-methoxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide → (3S)-2-Oxo-3-benzoylamino-5-acetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide

HRID 2230488노트

반응식

C(OC(=O)CN1C2C=CC=CC=2NC[C@H](NC(OC(C)(C)C)=O)C1=O)C1C=CC=CC=1.[O:32]=[C:33]1[N:39]([CH2:40][C:41]([NH:43][C@H:44]2[CH2:48][C:47](=[O:49])[O:46][CH:45]2[O:50][CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)=[O:42])[C:38]2[CH:58]=[CH:59][CH:60]=[CH:61][C:37]=2[N:36]([C:62](=[O:66])[CH2:63]OC)[CH2:35][C@@H:34]1[NH:67][C:68](=[O:78])[C:69]1[CH:74]=[C:73](Cl)[C:72](O)=[C:71](Cl)[CH:70]=1>>[O:32]=[C:33]1[N:39]([CH2:40][C:41]([NH:43][C@H:44]2[CH2:48][C:47](=[O:49])[O:46][CH:45]2[O:50][CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)=[O:42])[C:38]2[CH:58]=[CH:59][CH:60]=[CH:61][C:37]=2[N:36]([C:62](=[O:66])[CH3:63])[CH2:35][C@@H:34]1[NH:67][C:68](=[O:78])[C:69]1[CH:74]=[CH:73][CH:72]=[CH:71][CH:70]=1

참가 물질

반응물 2

HCID 22954562(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-methoxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide

HCID 57313411HCID 57313411, 화합물2회

생성물 1

HCID 22954569(3S)-2-Oxo-3-benzoylamino-5-acetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide

실험 절차

was synthesized from 600b via methods used to prepare 688a from 600b afford 30 mg of 693, 1H NMR (CD3OD) δ1.7(s, 3H), 1.8(s, 3H), 2.51(d, 1H, 2.6(m, 1H), 2.8(m, 1H), 3.0(m, 1H), 3.75(br. d, 2H), 4.0-4.1(dd, 2H), 4.5-5.0(m, 6H), 5.45(s, 1H), 5.55(s, 1H), 7.15-7.85(m, 14H).

출처 및 근거

ORD 기록: ord-22882444bf6f4ece8156e41a80e04ac9
출처 데이터셋: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06423840B1

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