Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 5-amino-o-anisate → Methyl5-isothiocyanato-2-methoxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 5-amino-o-anisate | HCID 89843 | — |
| 반응물 | O,O-Dipyridin-2-yl carbonothioate | HCID 719784 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl5-isothiocyanato-2-methoxybenzoate | HCID 18464541 | — |
반응 단계
According to the method of Tet. Let., 26, 1661 (1985), combine methyl 2-methoxy-5-aminobenzoate (0.5 g, 2.76 mmol) and di-2-pyridyl thionocarbonate (0.64 g, 2.76 mmol) in dichloromethane (10 mL). After 30 minutes, dilute the reaction mixture with dichloromethane and extract five times with water. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give methyl 2-methoxy-5-isothiocyanatobenzoate: Rf=0.51 (silica gel, dichloromethane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06423704B1 |
| 출처 데이터셋 | uspto-grants-2002_07 |
| ORD ID | ord-0b6053ef971143bcb0bef53115d2f0a5 |
| 출처 메모 | uspto-grants-2002_07 |