Styrene Oxide → HCID 10662045, 화합물
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:14]1[O:22][CH:15]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH2:14][CH:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[OH:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]참가 물질
4
실험 절차
A mixture of 100 g (0.55 mol) of 3,4-dimethoxyphenylethylamine and 66.2 g (0.55 mol) of styrene oxide in 200 ml of tetrahydrofuran was refluxed overnight. The solvent was removed in vacuo. About 500 ml of n-butyl chloride was added to the residue and the mixture cooled slightly. Filtration furnished N-[2-(3,4-dimethoxyphenyl)ethyl]-2-phenyl-2-hydroxyethylamine, m.p. 92°-93°.
후처리
- temperaturewas refluxed overnight
- customThe solvent was removed in vacuo
- additionAbout 500 ml of n-butyl chloride was added to the residue
- temperaturethe mixture cooled slightly
- filtrationFiltration
출처 및 근거
- ORD 기록
- ord-4bd8f5b96fc44887a7ce7f5b88688026
- 출처 데이터셋
- uspto-grants-1982_10
- 특허 번호
- US04352754
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