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Water → 4-(4-Methoxy-3-methylphenyl)-5-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)-1H-imidazole

HRID 2231111
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HRID 2231111 반응식
[F:1][C:2]([F:26])([F:25])[C:3]1[NH:4][C:5]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([CH3:24])[CH:17]=2)=[C:6]([C:8]2[CH:13]=[CH:12][C:11](SC)=[CH:10][CH:9]=2)[N:7]=1.O[O:28][S:29]([O-:31])=O.[K+].O1CCC[CH2:34]1.O>CO>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([C:5]2[N:4]=[C:3]([C:2]([F:26])([F:25])[F:1])[NH:7][C:6]=2[C:8]2[CH:13]=[CH:12][C:11]([S:29]([CH3:34])(=[O:31])=[O:28])=[CH:10][CH:9]=2)=[CH:17][C:18]=1[CH3:24]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 23707502Potassium hydroxy sulfiteHCID 178489082HCID 178489082, 화합물

생성물 1

HCID 184635424-(4-Methoxy-3-methylphenyl)-5-[4-(methylsulfonyl)phenyl]-2-(trifluoromethyl)-1H-imidazole수율 75%

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

The title compound was synthesized according to the procedure of Example 41, Step 4 using the product of Step 3 (1 g, 2.6 mmol) and Oxone®(4 g, 6.6 mmol) in methanol (20 ml), tetrahydrofuran (10 ml) and water (5 ml). The crude product was purified by chromatography on silica gel using 50% ethyl acetate in toluene as the eluent to give 610 mg (75%) of the desired product as a crystalline solid: mp 265-267° C. Anal. Calc'd. for C19H17N2F3O3S (MW 410.41): C, 55.60; H, 4.18; N, 6.83; S, 7.81. Found: C, 55.69; H, 4.28; N. 6.70; S, 8.07.

후처리

  1. customThe title compound was synthesized
  2. customThe crude product was purified by chromatography on silica gel using 50% ethyl acetate in toluene as the eluent

출처 및 근거

ORD 기록
ord-d4f8b83e75f74b28bcf6f6c40467b7bf
출처 데이터셋
uspto-grants-2002_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06426360B1

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