참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | [4-(Methylsulfanyl)phenyl]methanol | HCID 592968 | — |
| 반응물 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (4-Methanesulfonylphenyl)methanol | HCID 3801026 | 58% |
반응 단계
4-(Methylthio)benzyl alcohol (50 mmol, 7.71 g) was dissolved in methanol (150 ml) and cooled to 0° C. Oxone® (110 mmol, 67.6 g) in water (250 ml) was added. The stirred mixture was warmed to room temperature after 5 minutes. After 40 minutes, the mixture was diluted with water (250 ml), and extracted with methylene chloride (300 ml, then 2×100 ml). The combined organic layers were dried (MgSO4), filtered through silica, and concentrated to afford the title compound (5.48 g, 58%) as a waxy solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06426360B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_07 |
|---|
| ORD ID | ord-9af939ff7422411da39bebea0d53ba45 |
|---|
| 출처 메모 | uspto-grants-2002_07 |
|---|
