Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → 7-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | N-(2-Methoxyphenyl)piperazine hydrochloride | HCID 9899402 | — |
| 반응물 | 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one | HCID 19927734 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 7-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one | HCID 19927656 | 49% |
반응 단계
Method A (48 h at 60° C.); starting materials: 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one (example 70) and 1(2-methoxyphenyl)piperazine hydrochloride; yield 49%; fusion point 78°-80° C. (from isopropanol). Fumarate: method E; yield 82%; fusion point 149°-150° C. (from ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-0fe5b8d6421944b7bb370b3ad06c449c |
| 출처 메모 | uspto-grants-1995_06 |