Isopropanol → 7-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one

HRID 22312

반응식

HRID 22312 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([O:17][CH2:18][CH3:19])=[CH:8][C:9]2[O:14][C:13](=[O:15])[CH:12]=[CH:11][C:10]=2[CH:16]=1.Cl.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1.C(O)(C)C.C([O-])(=O)/C=C/C([O-])=O>C(O)C>[CH2:18]([O:17][C:7]1[C:6]([O:5][CH2:4][CH2:3][CH2:2][N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])[CH2:34][CH2:33]2)=[CH:16][C:10]2[CH:11]=[CH:12][C:13](=[O:15])[O:14][C:9]=2[CH:8]=1)[CH3:19]

참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 5460307FumarateHCID 9899402N-(2-Methoxyphenyl)piperazine hydrochlorideHCID 199277346-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one

생성물 1

HCID 199276567-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one수율 49%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Method A (48 h at 60° C.); starting materials: 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one (example 70) and 1(2-methoxyphenyl)piperazine hydrochloride; yield 49%; fusion point 78°-80° C. (from isopropanol). Fumarate: method E; yield 82%; fusion point 149°-150° C. (from ethanol).

후처리

  1. customMethod A (48 h at 60° C.)

출처 및 근거

ORD 기록
ord-0fe5b8d6421944b7bb370b3ad06c449c
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

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