Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Bis(4-fluorophenyl)methyl)piperazine → 7-{3-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Bis(4-fluorophenyl)methyl)piperazine | HCID 152932 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one | HCID 19927657 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 7-{3-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one | HCID 19927711 | 76% |
반응 단계
Method B (36 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one (example 68) and 1-[bis(4-fluorophenyl)methyl]-piperazine; yield 76% Ol. Fumarate: method E; yield 82%; fusion point 200°-202° C. (from acetone).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-68a7679b0ce54db087202d42cef063b1 |
| 출처 메모 | uspto-grants-1995_06 |