Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Methylumbelliferone | HCID 10748 | — |
| 반응물 | 4-Phenylpiperidine | HCID 69873 | — |
| 생성물 | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927702 | 55% |
반응 단계
Method A (4 h at 80° C.); starting materials: 6-[3-methanesulfonyloxy)propoxy]-7-methoxy-2H-1-benzopyran-2-one (example 67) and 4-phenylpiperidine; yield 55%; fusion point 123°-125° C. (from isopropanol). Hydrochloride: method G; yield 96%; fusion point 212°-215° C. (from isopropanol and ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-fe7a62813244417eabf620c30a56b95d |
| 출처 메모 | uspto-grants-1995_06 |