3-Amino-1-propanol → 2-t-Butyl-4-n-propyl-5-(3-hydroxypropylamino)-3(2H) pyridazinone

HRID 2231679노트

반응식

HRID 2231679 반응식
[C:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH3:14])=[C:8](Cl)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[OH:16][CH2:17][CH2:18][CH2:19][NH2:20].C(=O)([O-])[O-].[K+].[K+]>O>[C:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH3:14])=[C:8]([NH:20][CH2:19][CH2:18][CH2:17][OH:16])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 90863-Amino-1-propanolHCID 11430Potassium CarbonateHCID 199031582-t-butyl-4-n-propyl-5-chloro-3(2H)pyridazinone

생성물 1

HCID 139878402-t-Butyl-4-n-propyl-5-(3-hydroxypropylamino)-3(2H) pyridazinone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture comprising 14.0 g of 2-t-butyl-4-n-propyl-5-chloro-3(2H)pyridazinone, 44 g of 3-hydroxypropylamine and 14.8 g of anhydrous potassium carbonate, was stirred at a temperature of from 145° to 155° C. for 12.5 hours. The reaction solution was returned to room temperature, and about 200 ml of cold water was added. The mixture was stirred. The precipitated white crystals were collected by filtration, and dried to obtain 12.1 g of the above identified compound having a melting point of from 167° to 169° C.

후처리

  1. customwas returned to room temperature
  2. stirringThe mixture was stirred
  3. filtrationThe precipitated white crystals were collected by filtration
  4. customdried
  5. customto obtain 12.1 g of the
  6. customof from 167° to 169° C.

출처 및 근거

ORD 기록
ord-512a0777c6c84489a38e46f210ff83d3
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04783462

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