Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl methyl ether → 6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl methyl ether | HCID 15413 | — |
| 반응물 | 4-Phenylpiperidine | HCID 69873 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one | HCID 19927635 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927691 | 48% |
반응 단계
Method B (30 h at 45° C.); starting materials: 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one (example 72) and 4-phenylpiperidine; yield 48%; fusion point 96°-97° C. (from TBME and isopropanol). Fumarate: method E; yield 83%; fusion point 171°-173° C. (from acetone).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-54f2a4b0bf734d449f00a8d39ca228b9 |
| 출처 메모 | uspto-grants-1995_06 |