Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium borohydride → 2-Fluoro-4-(hydroxymethyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium borohydride | HCID 4148881 | — |
| 반응물 | Ethyl 4-cyano-3-fluorobenzoate | HCID 21284546 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-4-(hydroxymethyl)benzonitrile | HCID 11829631 | — |
반응 단계
40 g of ethyl 4-cyano-3-fluorobenzoate in 40 ml of THF are added dropwise to a solution of 8 g of LiBH4 in 120 ml of THF. In the course of this, the reaction mixture comes to the boil. After one hour it is acidified with 2NHCl and worked up in a customary manner. 3-Fluoro-4-cyanobenzyl alcohol, m.p. 70°-72° C., is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04784471 |
| 출처 데이터셋 | uspto-grants-1988_11 |
| ORD ID | ord-c8861f08df674d4b950967272d1f04b9 |
| 출처 메모 | uspto-grants-1988_11 |