Sodium Azide → HCID 14347788, 화합물
반응식
[CH2:1]([N:8]1[CH2:12][CH:11]([OH:13])[CH:10]([CH2:14]S(C)(=O)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:19]=[N+:20]=[N-:21].[Na+]>CO.O>[CH2:1]([N:8]1[CH2:12][CH:11]([OH:13])[CH:10]([CH2:14][N:19]=[N+:20]=[N-:21])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
1-Benzyl-4-hydroxy-3-methanesulfonylmethylpyrrolidine (80.8 g) is added to methanol-water (3:2) (1 liter), and thereto is added dropwise sodium azide (24.5 g), and the mixture is refluxed for 24 hours. After the reaction, the mixture is concentrated and extracted with dichloromethane. The dichloromethane solution is washed with water and saturated saline, dried and concentrated to give 1-benzyl-4-hydroxy-3-azidomethylpyrrolidine (59.7 g) as an oil.
후처리
- temperaturethe mixture is refluxed for 24 hours
- customAfter the reaction
- concentrationthe mixture is concentrated
- extractionextracted with dichloromethane
- washThe dichloromethane solution is washed with water and saturated saline
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-fea7f18239074fdd98a287d80d88940a
- 출처 데이터셋
- uspto-grants-1988_11
- 특허 번호
- US04786649
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