Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (+/-)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| 반응물 | 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927672 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (+/-)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one | HCID 19927673 | 69% |
반응 단계
Method C (3 d at 40° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-hydroxy-4-phenylpiperidine; yield 69%; fusion point 155°-157° C. (from isopropanol). Hydrochloride: method G; yield 88%; fusion point 202°-203° C. (from isopropanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-6c21ad51386049a890bf9e863962f865 |
| 출처 메모 | uspto-grants-1995_06 |