Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) → 1-(2-chloroethoxy)-3-nitrobenzene

HRID 2232318노트

반응식

HRID 2232318 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[Cl:17][CH2:18][CH2:19]OS(C1C=CC(C)=CC=1)(=O)=O>CC(=O)CC>[Cl:17][CH2:18][CH2:19][O:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

참가 물질

5

반응물 3

HCID 6639Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate)HCID 111373-NitrophenolHCID 11430Potassium Carbonate

생성물 1

HCID 43044241-(2-chloroethoxy)-3-nitrobenzene

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 6.96 g. of m-nitrophenol, 100 ml. of 2-butanone, 6.9 g. of potassium carbonate, and 11.74 g. of 2 chloroethyl-tosylate was stirred and heated under reflux for 24 hours. After cooling to room temperature, the salts were filtered off and the filtrate concentrated under vacuum. The residue crystallized on seeding and was recrystallized from carbon tetrachloride to give 8.3 g. of product, m.p. 54.5°-57° C.

후처리

  1. additionA mixture of 6.96 g
  2. temperatureheated
  3. temperatureunder reflux for 24 hours
  4. filtrationthe salts were filtered off
  5. concentrationthe filtrate concentrated under vacuum
  6. customThe residue crystallized on seeding
  7. customwas recrystallized from carbon tetrachloride
  8. customto give 8.3 g

출처 및 근거

ORD 기록
ord-e7eec975577a49738e06e58d397b4c33
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04788195

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