Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzamide

HRID 2232643노트

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HRID 2232643 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 140963672,3-Dichloro-4,5-difluorobenzonitrile

생성물 1

HCID 140963682,3-Dichloro-4,5-difluorobenzamide

실험 절차

A solution of 2,3-dichloro-4,5-difluorobenzonitrile (1.0 g) in concentrated sulfuric acid (2.5 ml) was stirred at 90° to 100° C. for 30 minutes and then cooled. The residue was poured into ice water and the resulting precipitate was collected by filtration and recrystallized from benzene to give the title compound (0.51 g) as colorless needles, mp 153°-155° C.

후처리

  1. temperaturecooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from benzene

출처 및 근거

ORD 기록
ord-83c42384b2eb40df9ff8dc5fc64473f5
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04788320

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