Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 2232645노트

반응식

HRID 2232645 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

생성물 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

실험 절차

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

후처리

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

출처 및 근거

ORD 기록
ord-ea06f8b905af4ef39127de398d3ba8e4
출처 데이터셋
uspto-grants-1988_11
특허 번호
US04788320

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