Phenyl isocyanate → 1-(2-dimethylaminoethyl)-3-phenylurea

HRID 223275노트

반응식

HRID 223275 반응식
[CH3:1][N:2]([CH2:4][CH2:5][NH2:6])[CH3:3].[C:7]1([N:13]=[C:14]=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1(C)C=CC=CC=1>[C:7]1([NH:13][C:14]([NH:6][CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 66053N,N-Dimethylethylenediamine

생성물 1

HCID 15265811-(2-dimethylaminoethyl)-3-phenylurea

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

88 g of dimethylaminoethylamine are dissolved in 500 l of toluene and then 119 g of phenyl isocyanate are added dropwise in the course of 10 minutes, whereupon the temperature rises to 97° C. The mixture is refluxed for 4 hours. On cooling, the product crystallises and is filtered with suction. The moist product is recrystallised from 1000 ml of ethyl acetate. Yield: 135 g (65.1%); m.p. 141°-142° C.

후처리

  1. customrises to 97° C
  2. temperatureThe mixture is refluxed for 4 hours
  3. temperatureOn cooling
  4. customthe product crystallises
  5. filtrationis filtered with suction
  6. customThe moist product is recrystallised from 1000 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-c2154438549241f3a25316de9488dbb0
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04352913

반응 노트

불러오는 중…