Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3-Chloropropyl)-4-phenylpiperidine → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927739 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927695 | 45% |
반응 단계
Method D (3 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one (example 104) and 1-(3-chloropropyl)-4-phenylpiperidine; yield 45%; fusion point 125°-126° C. (from TBME and methanol). Fumarate: method E; yield 59%; fusion point 176°-179° C. (from ethanol and TBME).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-ee803333f37a47e09dae10cb3370c666 |
| 출처 메모 | uspto-grants-1995_06 |