Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl methyl ether → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl methyl ether | HCID 15413 | — |
| 반응물 | 4-Phenylpiperidine | HCID 69873 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one | HCID 19927738 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one | HCID 19927725 | 54% |
반응 단계
Method A (20 h at 60° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one (example 76) and 4-phenylpiperidine; yield 54%; fusion point 101°-102° C. (from TBME and petroleum ether). Fumarate: method E; yield 62%; fusion point 191°-194° C. (from acetone and methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-f6916d529fe9473aa2dc8d74fbd0b5a2 |
| 출처 메모 | uspto-grants-1995_06 |