Ethanolamine → HCID 68678087, 화합물

HRID 2233019노트

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HRID 2233019 반응식
[C:1]([C:5]1[N:6]=[C:7](Cl)[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:16]([CH2:18][NH2:19])[OH:17]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([NH:19][CH2:18][CH2:16][OH:17])[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 68676527HCID 68676527, 화합물

생성물 1

HCID 68678087HCID 68678087, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 0.50 g of the product of Step F and 0.40 g of ethanolamine in THF (6 mL) was heated at reflux for 16 h. After cooling the reaction mixture to ambient temperature, solvents were removed and the residue was purified by silica gel chromatography to yield the title compound as a white solid. MS (M+H+)=252.3.

후처리

  1. temperatureat reflux for 16 h
  2. customsolvents were removed
  3. customthe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-543f1bd9aebb4f73add199eacbf683b5
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709473B2

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