Sodium Methoxide → 7-Fluoro-2-methoxy-8-methylquinoxaline
반응식
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[C:5]([CH3:13])[C:6]([F:12])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+]>CO>[F:12][C:6]1[C:5]([CH3:13])=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:15][CH3:14])=[N:3]2)=[CH:8][CH:7]=1참가 물질
4
실험 절차
2-Chloro-7-fluoro-8-methylquinoxaline (4.1 g, 20.9 mmol) was suspended in dry methanol and a 25% solution of sodium methoxide in methanol (4.73 ml, 21.9 mmol) was added by syringe. The mixture was heated under reflux for 2 h, then evaporated. The residue was dissolved in dichloromethane and water and the phases were separated. The aqueous phase was extracted twice with dichloromethane, and combined organic fractions were dried and evaporated to give product (3.84 g, 96%).
후처리
- temperatureThe mixture was heated
- temperatureunder reflux for 2 h
- customevaporated
- dissolutionThe residue was dissolved in dichloromethane
- customwater and the phases were separated
- extractionThe aqueous phase was extracted twice with dichloromethane
- customwere dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-a142b70347a1436ba085ad7f7903088e
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07709483B2
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