HCID 86628018, 화합물 → 8-Bromo-6-chloro-2H-1-benzopyran-2-one

HRID 2233327노트

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HRID 2233327 반응식
[Br:1][C:2]1[C:3]([OH:15])=[C:4](/[CH:9]=[CH:10]/[C:11]([O:13]C)=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1>C1C2C(CCCC2)CCC1>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]2[C:3]=1[O:15][C:11](=[O:13])[CH:10]=[CH:9]2

참가 물질

3

반응물 1

HCID 86628018HCID 86628018, 화합물

생성물 1

HCID 187215758-Bromo-6-chloro-2H-1-benzopyran-2-one수율 95%

시약·촉매·용매 1

HCID 7044Decalin용매

실험 절차

A solution of methyl (2E)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-2-propenoate (1.45 g; 5.0 mmol) in decalin (5 mL) was heated in a sand bath at 200° C. for 48 h. The reaction was then cooled to RT and hexanes (10 mL) was added. The solid was collected by suction filtration and washed with hexanes. Drying under high vacuum gave the title compound (1.2 g, 95%) as a tan solid: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (s, 1H), 7.63 (d, J=9.6 Hz, 1H)), 7.46 (s, 1H), 6.52 (d, J=9.6 Hz, 1H); MS (ES) m/e 259, 261 (M+H)+.

후처리

  1. filtrationThe solid was collected by suction filtration
  2. washwashed with hexanes
  3. customDrying under high vacuum

출처 및 근거

ORD 기록
ord-ae449f223cad4c949e91e431095a06b8
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709496B2

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