Cesium carbonate → 4-Chloro-6-[2,2,2-trifluoro-1-(4-furan-3-yl-phenyl)-ethoxy]-pyrimidin-2-ylamine

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	1,4-Dioxane	HCID 31275	—
반응물	2-Amino-4,6-dichloropyrimidine	HCID 65522	—
반응물	2,2,2-Trifluoro-1-(4-furan-3-yl-phenyl)-ethanol	HCID 66743604	—
용매	Ethyl Acetate	HCID 8857	—
생성물	4-Chloro-6-[2,2,2-trifluoro-1-(4-furan-3-yl-phenyl)-ethoxy]-pyrimidin-2-ylamine	HCID 86621086	82.6%

반응 조건

온도	110 °C

반응 단계

The mixture of 2,2,2-trifluoro-1-(4-furan-3-yl-phenyl)-ethanol (100 mg, 0.4 mmol), 2-amino-4,6-dichloro-pyrimidine (60 mg, 0.36 mmol), cesium carbonate (468 mg, 1.44 mmol) and 1,4-dioxane (1 ml) was heated at 110° C. overnight. The reaction mixture was cooled to room temperature; 10 ml of ethyl acetate was added. The mixture was then filtered through Celite, the filtrate was concentrated to give 110 mg of 4-chloro-6-[2,2,2-trifluoro-1-(4-furan-3-yl-phenyl)-ethoxy]-pyrimidin-2-ylamine, yield: 72%.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07709493B2
출처 데이터셋	uspto-grants-2010_05
ORD ID	ord-d299f9c5145347a28a614adc960327e5
출처 메모	uspto-grants-2010_05