Sulmazole → 2-(2-Methoxy-4-methylsulfinyl-phenyl)-6-hydroxy-1H-imidazo[4,5-b]pyridine

HRID 223358

반응식

HRID 223358 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2.C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=[O:26].O=C1O[C@H]([C@H](CO)O)C(O)=C1O>P([O-])([O-])([O-])=O.OO.S([O-])([O-])(=O)=O.[Fe+2]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[C:18]([OH:26])[CH:19]=2

참가 물질

7

반응물 3

HCID 5353SulmazoleHCID 6049Ethylenediaminetetraacetic AcidHCID 54670067L-Ascorbic Acid

생성물 1

HCID 130368152-(2-Methoxy-4-methylsulfinyl-phenyl)-6-hydroxy-1H-imidazo[4,5-b]pyridine

시약·촉매·용매 3

HCID 24393Ferrous Sulfate촉매HCID 784Hydrogen Peroxide용매HCID 1061Phosphate용매2회

실험 절차

7.2 gm of 2-(2-methoxy-4-methylsulfinyl-phenyl)-1H-imidazo[4,5-b]pyridine were dissolved in a mixture of a phosphate buffer of pH 7.2 and 120 ml of 3% hydrogen peroxide, and a solution of 9.3 gm of ethylenediamine tetraacetic acid, 4.4 gm of ascorbic acid, 3.8 gm of iron(II) sulfate in a phosphate buffer of pH 7.2 was added. After 30 minutes the reaction mixture was evaporated in vacuo, and the residue was purified by chromatography on a polystyrene resin column (XAD-2 of Rohm & Haas) with water and methanol as eluants. After evaporation of the eluate the two compounds were separated by means of chromatography on silicagel [eluant: chloroform/methanol/ammonia water=85/15/2 (v/v)]. 2-(2-Methoxy-4-methylsulfinyl-phenyl)-6-hydroxy-1H-imidazo[4,5-b]pyridine was obtained as yellow powder.

후처리

  1. customAfter 30 minutes the reaction mixture was evaporated in vacuo
  2. customthe residue was purified by chromatography on a polystyrene resin column (XAD-2 of Rohm & Haas) with water and methanol as eluants
  3. customAfter evaporation of the eluate the two compounds
  4. customwere separated by means of chromatography on silicagel [eluant: chloroform/methanol/ammonia water=85/15/2 (v/v)]

출처 및 근거

ORD 기록
ord-82029858ee1c4b3dbc75f90598e80ee4
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04353909

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