Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2233666생성일: 2026년 10월 25일
Triethylamine → 4-[3-(4-Hydroxyphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
https://huagongshe.com/reaction/2233666
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(4-Hydroxyphenylamino)-2-methylpropanenitrile | HCID 350269 | — |
| 반응물 | 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile | HCID 11615540 | — |
| 반응물 | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[3-(4-Hydroxyphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile | HCID 86609853 | 34% |
반응 단계
Triethylamine (0.101 g, 1 mmol) was added to a solution of 1a (0.456 g, 2 mmol) and 3a (0.352 g, 2 mmol) in dry THF (5 ml). The reaction mixture was stirred at 0° C. for 48 h and then concentrated to yield a dark residue which was subjected to flash chromatography (dichloromethane/acetone, 85:15) to afford 4-[3-(4-hydroxyphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile, 3b (0.274 g, 0.68 mmol, 34%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07709517B2 |
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| 출처 데이터셋 | uspto-grants-2010_05 |
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| ORD ID | ord-4ef9acb4197a40139591727e6520ab86 |
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| 출처 메모 | uspto-grants-2010_05 |
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