1-(4-Chlorophenoxy)acetone → HCID 68617744, 화합물

HRID 2233741노트

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HRID 2233741 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11]N.[Cl:13][C:14]1[CH:24]=[CH:23][C:17]([O:18][CH2:19][C:20](=O)[CH3:21])=[CH:16][CH:15]=1>CC#N.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]2[C:3]=1[NH:11][C:20]([CH3:21])=[C:19]2[O:18][C:17]1[CH:16]=[CH:15][C:14]([Cl:13])=[CH:24][CH:23]=1

참가 물질

5

반응물 2

HCID 2398741-(4-Chlorophenoxy)acetoneHCID 53402499(2-Bromo-5-nitrophenyl)hydrazine

생성물 1

HCID 68617744HCID 68617744, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

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온도
75 °C

실험 절차

A mixture of the compound from (i) (2.4 g) and 1-(4-Chloro-phenoxy)-propan-2-one (1.65 g) in MeCN (20 ml) and water (5 ml) was stirred for 16 h. The volatiles were removed in vacuo. AcOH (50 ml) was added and the reaction heated at 75° C. for 72 h. The volatiles were evaporated under reduced pressure and the residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane. Yield 0.34 g

후처리

  1. customThe volatiles were removed in vacuo
  2. additionAcOH (50 ml) was added
  3. customThe volatiles were evaporated under reduced pressure
  4. customthe residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane

출처 및 근거

ORD 기록
ord-bd892b9f6f3440b48b6590ad1fbadcc5
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709521B2

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