Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 3-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 반응물 | 3-(4-chlorophenoxy)-2-methyl-5-(methylthio)-1H-indole-1-acetic acid, methyl ester | HCID 86609233 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester | HCID 86609234 | — |
반응 단계
To the product from step (ii) (0.32 g) in acetone (4 ml) and water (4 ml) was added solid sodium bicarbionate (0.57 g) followed by oxone (0.69 g in water (2.5 ml)) and the reaction was stirred for 3 h. The reaction was quenched with sodium bisulfite and partitioned between ethylacetate/water. The organics were dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 30-60% ethylacetate/iso-hexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07709521B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-25c48a8c9dae42f5a2b6048ee26a90da |
| 출처 메모 | uspto-grants-2010_05 |