Acetone → 3-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester

HRID 2233749

반응식

HRID 2233749 반응식
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13](SC)[CH:14]=3)[N:9]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:8]=2[CH3:23])=[CH:4][CH:3]=1.[Na].O[O:28][S:29]([O-:31])=O.[K+].[CH3:33]C(C)=O>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([S:29]([CH3:33])(=[O:31])=[O:28])[CH:14]=3)[N:9]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[C:8]=2[CH3:23])=[CH:24][CH:25]=1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 5360545SodiumHCID 23707502Potassium hydroxy sulfiteHCID 866092333-(4-chlorophenoxy)-2-methyl-5-(methylthio)-1H-indole-1-acetic acid, methyl ester

생성물 1

HCID 866092343-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid, methyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To the product from step (ii) (0.32 g) in acetone (4 ml) and water (4 ml) was added solid sodium bicarbionate (0.57 g) followed by oxone (0.69 g in water (2.5 ml)) and the reaction was stirred for 3 h. The reaction was quenched with sodium bisulfite and partitioned between ethylacetate/water. The organics were dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 30-60% ethylacetate/iso-hexane.

후처리

  1. customThe reaction was quenched with sodium bisulfite
  2. custompartitioned between ethylacetate/water
  3. customThe organics were dried
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica eluting with 30-60% ethylacetate/iso-hexane

출처 및 근거

ORD 기록
ord-25c48a8c9dae42f5a2b6048ee26a90da
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709521B2

연결된 노트

불러오는 중…