trimethylsilyldiazomethane Et2O → 3-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid methyl ester

HRID 2233825

반응식

HRID 2233825 반응식
[C:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[NH:5][C:4]=1[C:10]([OH:12])=[O:11])#[N:2].[CH3:13][Si](C=[N+]=[N-])(C)C.CCOCC>C1COCC1>[CH3:13][O:11][C:10]([C:4]1[NH:5][C:6]([CH2:8][CH3:9])=[CH:7][C:3]=1[C:1]#[N:2])=[O:12]

참가 물질

4

반응물 2

HCID 23159941trimethylsilyldiazomethane Et2OHCID 685798453-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid2회

생성물 1

HCID 685798823-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 31) (500 mg) was dissolved in anhydrous THF (5 ml) and cooled to 0° C. (Trimethylsilyl)diazomethane/ether (2 ml) was added. The mixture was stirred at room temperature under nitrogen gas for 1 h. The solvent was removed in vacuo and MeOH was added. The mixture was stirred for a further 15 min, the solvent was removed in vacuo and the solid was dried under vacuum to give the title compound (580 mg).

후처리

  1. additionwas added
  2. customThe solvent was removed in vacuo and MeOH
  3. additionwas added
  4. stirringThe mixture was stirred for a further 15 min
  5. customthe solvent was removed in vacuo
  6. customthe solid was dried under vacuum

출처 및 근거

ORD 기록
ord-a5d960cc378b41489494d9ce2201c888
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709503B2

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