1,4-Dioxane hydrochloride → 2-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride

HRID 2233861노트

반응식

HRID 2233861 반응식
Cl.O1CCOCC1.[NH2:8][C:9]([C:11]1[CH:16]=[C:15]([Cl:17])[N:14]=[C:13]([N:18]2[CH2:23][CH2:22][CH:21]([NH:24]C(=O)OC(C)(C)C)[CH2:20][CH2:19]2)[CH:12]=1)=[O:10]>>[ClH:17].[NH2:24][CH:21]1[CH2:20][CH2:19][N:18]([C:13]2[CH:12]=[C:11]([CH:16]=[C:15]([Cl:17])[N:14]=2)[C:9]([NH2:8])=[O:10])[CH2:23][CH2:22]1

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86608240tert-Butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate2회

생성물 1

HCID 866082552-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride수율 211.9%

실험 절차

4 N HCl/Dioxane solution (6 ml) was added to tert-butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate (Intermediate 16, 100 mg, 0.282 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo and the anhydrous diethylether (25 ml) was added. The solvent was removed in vacuo and light yellow solid that resulted was dried under vacuum for several hours to give the title compound as an off-white solid (87 mg).

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe anhydrous diethylether (25 ml) was added
  3. customThe solvent was removed in vacuo and light yellow solid
  4. customthat resulted
  5. customwas dried under vacuum for several hours

출처 및 근거

ORD 기록
ord-010a6720b8aa45399fc14b563c0b0bfa
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709503B2

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