Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Chloro-2-benzothiazolamine → 2-Amino-6-fluorobenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Chloro-2-benzothiazolamine | HCID 7226 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | Chlorine | HCID 24526 | — |
| 반응물 | 2,6-Dichlorobenzothiazole | HCID 77176 | — |
| 반응물 | 2-Chloro-6-fluorobenzothiazole | HCID 2049870 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 생성물 | 2-Amino-6-fluorobenzothiazole | HCID 319954 | — |
반응 단계
The starting compounds of the formula III wherein X is chlorine or bromine can be prepared from corresponding 2-benzothiazole-amines by reaction with a warm concentrated hydrohalic acid and sodium nitrite [See H. Mazzone and G. Pappalardo, Il Farmaco, Ed. Sc. 32, 348-354 (1977)]. Thus, for example, 2,6-dichlorobenzothiazole (m.p. 99°-101° C.) can be obtained from 6-chloro-2-benzothiazole-amine, and 2-chloro-6-fluorobenzothiazole (m.p. 92°-93° C.) can be obtained from 6-fluoro-2-benzothiazole-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04353919 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-b453363a4d5f450080ec690120e5aa05 |
| 출처 메모 | uspto-grants-1982_10 |