Sulfuryl chloride → Ethyl 2-chloro-4-(2-methoxyethoxy)-3-oxobutanoate
반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][C:7](=[O:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].S(Cl)([Cl:18])(=O)=O>C(Cl)Cl.CCOC(C)=O>[Cl:18][CH:8]([C:7](=[O:14])[CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[C:9]([O:11][CH2:12][CH3:13])=[O:10]참가 물질
5
실험 절차
Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate (Intermediate 123) (0.5 g) was dissolved in anhydrous DCM (5 ml). Sulfuryl chloride (430 mg) was added dropwise at room temperature. The mixture was stirred for 6 h. The crude mixture was diluted with EtOAc (50 ml) and washed well with water and brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound as a light orange oil (414 mg).
후처리
- washwashed well with water and brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-339bde1c8c6b42179d06964ffd5121b5
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07709503B2
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