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Ammonium Chloride → HCID 178433661, 화합물

HRID 2233942
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HRID 2233942 반응식
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([O:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]#[N:25])[CH:21]=[C:20]([Cl:26])[N:19]=2)[CH2:14][CH2:13]1)=[O:10].[N-:27]=[N+:28]=[N-:29].[Na+].[Cl-].[NH4+]>CN(C=O)C>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([O:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[CH:23]=[C:22]([C:24]3[NH:29][N:28]=[N:27][N:25]=3)[CH:21]=[C:20]([Cl:26])[N:19]=2)[CH2:16][CH2:17]1)=[O:10]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

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HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 866082941-(6-Chloro-4-cyanopyridin-2-yl)piperidin-4-yl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 178433661HCID 178433661, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
120 °C

실험 절차

1-(6-Chloro-4-cyanopyridin-2-yl)piperidin-4-yl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate (Example 308, 64 mg, 0.154 mmol), sodium azide (12 mg, 0.185 mmol) and ammonium chloride (8.3 mg, 0.154 mmol) were dissolved in anhydrous DMF (2 ml) and the mixture was heated at 120° C. for 8 h. The mixture was filtered and purified my semi-preparative reverse phase HPLC eluting with CH3CN/H2O (0.1% TFA) (48 mg).

후처리

  1. filtrationThe mixture was filtered
  2. custompurified my semi-preparative reverse phase HPLC
  3. washeluting with CH3CN/H2O (0.1% TFA) (48 mg)

출처 및 근거

ORD 기록
ord-08f34756443649acb495a099b66f7f02
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07709503B2

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