Ethanol → O-Ethyl (3-Chlorophenyl)-thiocarbamate

HRID 223395

반응식

HRID 223395 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[S:10])[CH:5]=[CH:6][CH:7]=1.N1C2C(=CC=CC=2)C=CC=1.[CH2:21]([OH:23])[CH3:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[S:10])[O:23][CH2:21][CH3:22])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 7047QuinolineHCID 754493-Chlorophenyl isothiocyanate

생성물 1

HCID 54084842O-Ethyl (3-Chlorophenyl)-thiocarbamate

실험 절차

A mixture of 45.5 gm (0.268 mol) of 3-chlorophenylisothiocyanate, 200 ml of anhydrous ethanol and 1 ml of quinoline was refluxed for 48 hours. Then, the reaction mixture was evaporated in an aspirator vacuum, the residue was taken up in ether, and the resulting solution was washed first with 5% hydrochloric acid and then thoroughly with water, dried, and evaporated again. After recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C. were obtained.

후처리

  1. temperaturewas refluxed for 48 hours
  2. customThen, the reaction mixture was evaporated in an aspirator vacuum
  3. washthe resulting solution was washed first with 5% hydrochloric acid
  4. dry with materialthoroughly with water, dried
  5. customevaporated again
  6. customAfter recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C.
  7. customwere obtained

출처 및 근거

ORD 기록
ord-0314404d9a3246f4a990bc889874e10e
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04353919

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