Ethanol → O-Ethyl (3-Chlorophenyl)-thiocarbamate

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[S:10])[CH:5]=[CH:6][CH:7]=1.N1C2C(=CC=CC=2)C=CC=1.[CH2:21]([OH:23])[CH3:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[S:10])[O:23][CH2:21][CH3:22])[CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 702Ethanol

HCID 7047Quinoline

HCID 754493-Chlorophenyl isothiocyanate

생성물 1

HCID 54084842O-Ethyl (3-Chlorophenyl)-thiocarbamate

실험 절차

A mixture of 45.5 gm (0.268 mol) of 3-chlorophenylisothiocyanate, 200 ml of anhydrous ethanol and 1 ml of quinoline was refluxed for 48 hours. Then, the reaction mixture was evaporated in an aspirator vacuum, the residue was taken up in ether, and the resulting solution was washed first with 5% hydrochloric acid and then thoroughly with water, dried, and evaporated again. After recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C. were obtained.

후처리

temperaturewas refluxed for 48 hours
customThen, the reaction mixture was evaporated in an aspirator vacuum
washthe resulting solution was washed first with 5% hydrochloric acid
dry with materialthoroughly with water, dried
customevaporated again
customAfter recrystallization from methanol/water, 49.5 gm (86% of theory) of colorless crystals with a melting point of 78°-79° C.
customwere obtained

출처 및 근거

ORD 기록: ord-0314404d9a3246f4a990bc889874e10e
출처 데이터셋: uspto-grants-1982_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04353919

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