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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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m-Chloroperbenzoic acid → 2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-N-methoxy-6-(methylsulfonyl)isonicotinamide

HRID 2233977
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HRID 2233977 반응식
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:26]=[C:27]([S:29]([CH3:31])=[O:30])[N:28]=2)[C:21]([NH:23][O:24][CH3:25])=[O:22])[CH2:14][CH2:13]1)=[O:10].C1C=C(Cl)C=C(C(OO)=[O:40])C=1>C(Cl)Cl>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([C:18]2[CH:19]=[C:20]([CH:26]=[C:27]([S:29]([CH3:31])(=[O:40])=[O:30])[N:28]=2)[C:21]([NH:23][O:24][CH3:25])=[O:22])[CH2:16][CH2:17]1)=[O:10]
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반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 866083232-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-N-methoxy-6-(methylsulfinyl)isonicotinamide

생성물 1

HCID 112029112-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-N-methoxy-6-(methylsulfonyl)isonicotinamide수율 11.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-N-methoxy-6-(methylsulfinyl)isonicotinamide (Example 152) (90 mg, 0.185 mmol) was dissolved in anhydrous DCM (5 ml). mCPBA (32 mg, 0185 mmol) was added and the mixture was stirred at room temperature for 12 h. The crude mixture was diluted and washed with 10% sodium thiosulfate, water, brine and dried over sodium sulfate and concentrated in vacuo. The brown oil was purified by flash chromatography eluting with acetonitrile/water (0.1% TFA) to give the title compound (11 mg).

후처리

  1. washwashed with 10% sodium thiosulfate, water, brine
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe brown oil was purified by flash chromatography
  5. washeluting with acetonitrile/water (0.1% TFA)

출처 및 근거

ORD 기록
ord-237cfaf1f049413dbc3247154b7c9501
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07709503B2

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