HCID 68579940, 화합물 → 6-(4-{[(3,4-Dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylic acid
반응식
ClC1C(Cl)=C(C)NC=1C(NC1CCN(C2SC=CN=2)CC1)=O.[Cl:23][C:24]1[C:28]([Cl:29])=[C:27]([CH3:30])[NH:26][C:25]=1[C:31]([NH:33][CH:34]1[CH2:39][CH2:38][N:37]([C:40]2[N:45]=[C:44]([N:46]3[CH2:50][CH2:49][CH2:48][CH2:47]3)[N:43]=[C:42]([C:51]([O:53]C)=[O:52])[CH:41]=2)[CH2:36][CH2:35]1)=[O:32]>>[Cl:23][C:24]1[C:28]([Cl:29])=[C:27]([CH3:30])[NH:26][C:25]=1[C:31]([NH:33][CH:34]1[CH2:39][CH2:38][N:37]([C:40]2[N:45]=[C:44]([N:46]3[CH2:50][CH2:49][CH2:48][CH2:47]3)[N:43]=[C:42]([C:51]([OH:53])=[O:52])[CH:41]=2)[CH2:36][CH2:35]1)=[O:32]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was synthesized by an analogous method to Intermediate 3 starting from methyl 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-pyrrolidin-1-ylpyrimidine-4-carboxylate (Example 316).