Benzyl Alcohol → Benzyl 2-bromopropanoate
반응식
[Br:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(OCC)C>[Br:1][CH:2]([CH3:6])[C:3]([O:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]참가 물질
5
실험 절차
2-Bromopropionyl chloride (213.4 g) was added dropwise to benzyl alcohol (145.8 g) with stirring under a stream of nitrogen, keeping the temperature of the reaction mixture below 30° C. by cooling with cold water. When all the acid chloride has been added, the mixture was stirred for another two hours at ambient temperature. The reaction mixture was then diluted with diethyl ether (200 ml) and washed with water until free of acid. The ethereal solution was dried and evaporated and the residue distilled to give benzyl 2-bromopropionate, b.p. 82°-85°/0.5 Torr.
후처리
- customthe temperature of the reaction mixture below 30° C.
- stirringthe mixture was stirred for another two hours at ambient temperature
- washwashed with water until free of acid
- customThe ethereal solution was dried
- customevaporated
- distillationthe residue distilled
출처 및 근거
- ORD 기록
- ord-1c00f06cea1740ed92e24c97ab00991d
- 출처 데이터셋
- uspto-grants-1982_10
- 특허 번호
- US04354034
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