Benzyl Alcohol → Benzyl 2-bromopropanoate

HRID 223420

반응식

HRID 223420 반응식
[Br:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(OCC)C>[Br:1][CH:2]([CH3:6])[C:3]([O:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 962WaterHCID 979802-Bromopropanoyl chloride

생성물 1

HCID 298874Benzyl 2-bromopropanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2-Bromopropionyl chloride (213.4 g) was added dropwise to benzyl alcohol (145.8 g) with stirring under a stream of nitrogen, keeping the temperature of the reaction mixture below 30° C. by cooling with cold water. When all the acid chloride has been added, the mixture was stirred for another two hours at ambient temperature. The reaction mixture was then diluted with diethyl ether (200 ml) and washed with water until free of acid. The ethereal solution was dried and evaporated and the residue distilled to give benzyl 2-bromopropionate, b.p. 82°-85°/0.5 Torr.

후처리

  1. customthe temperature of the reaction mixture below 30° C.
  2. stirringthe mixture was stirred for another two hours at ambient temperature
  3. washwashed with water until free of acid
  4. customThe ethereal solution was dried
  5. customevaporated
  6. distillationthe residue distilled

출처 및 근거

ORD 기록
ord-1c00f06cea1740ed92e24c97ab00991d
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04354034

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